Professor Kim Watson - Meet the team

Kim Watson

Email:
k.a.watson@reading.ac.uk
Phone:
+44 (0) 118 378 6640
Job title:
Professor

Responsibilities:

Professor in Structural Biochemistry

Building location

HLS Room 2.02

Teaching

Part 1: Foundation Biology
Part 2: Protein Structure and Function
Part 3: Structural Proteomics and Synthetic Biology

Research centres and groups

Member of

Institute for Cardiovascular & Metabolic Research
Molecular & Cellular Medicine Group

Research projects

Funding from BBSRC, Lister Institute of Preventive Medicine, Diamond Light Source, Industry
Unravelling sequence-structure-function relationships of proteinsТ
Drug discovery using computer-aided and structure-based approaches
Protein engineering for industry
Understanding molecular mechanisms of disease
Bile acid metabolism, lipid profiling and health
Gut-liver-brain axis and healthТ

Awards and honours

Esteem Factors

Fellow of the Royal Society of Chemistry
Fellow of the Royal Society of Biology and Chartered Biologist
Fellow Member, Lister Institute of Preventive Medicine
Fellow of the Higher Education Academy
Visiting Scientist, MRC Harwell International Centre for Mouse Genetics
Visiting Scientist, Diamond Light Source

Professional bodies/affiliations

Impact, Enterprise and Outreach

Consultant to Industry for computational and structural biology for drug discovery and engineering enzymes for biotechnology
Development of lead compounds and pharmacophores for drug discovery
Development and delivery of biopharma skills training for Industry
Experience of working with a number of Government organisations
Numerous outreach activities to promote student awareness of STEM research
Highlighted in 'Women in Research', a photographic exhibition to celebrate women in research at the 91ЕМКН

International Collaborators

Prof. Gabriele Cruciani, University of Perugia, Italy
Dr. Edda Battaglia, Gastroenterology, Cardinal Massaia Hospital, Asti, Italy

National Collaborators

Prof. Glenn Gibson, Food Biosciences, 91ЕМКН
Dr. Eva Kevei, Biological Sciences, 91ЕМКН
Prof. Heather Mortiboys, Sheffield Institute of Translational Neuroscience
Prof. Oliver Bandmann, Consultant Neurologist, Sheffield Institute of Translational Neuroscience
Dr. Roger Cox, MRC Harwell International Centre for Mouse Genetics

Websites/blogs

Study for a PhD with Professor Kim Watson

Selected publications

Pre 2005

Watson KA, Johnson LNJ, Leoffen P, Gillham D, Eggleston D, Collins P, Moynihan JM, DTI government report (2004) "Structural Genomics in Japan and China" following invitation to coordinate and lead a fully funded DTI mission. The report describes the findings from a DTI funded mission to China and Japan to explore emerging HTP technologies and provide opportunities for UK collaboration/technology transfer.

Brown, K., Carpenter E.,Т Watson, KA, Coggins, JR, Hawkins, AR, Koch, MH, Svergun, DI. (2003) "Twists and turns: a tale of two shikimate-pathway enzymes."Т Biochem. Soc. Trans.,Т 31, 543-547.

Nathalie Marchand-Geneste,Т Kimberly A. Watson, Bjorn K. Alsberg, and Ross D. King, (2002) "New Approach to Pharmacophore Mapping and QSAR Analysis Using Inductive Logic Programming. Application to Thermolysin Inhibitors and Glycogen Phosphorylase b Inhibitors".J. Med. Chem., 45, 399-409.

Katerina Tsitsanou, Nikos G. Oikonomakos, Spiros E. Zographos, V. Skamnaki, Mary Gregoriou,Т Kimberly A. Watson, Louise N. Johnson, George W.J. Fleet,Т Protein Science, 1999, 8, 741-749. "Effect of commonly used cryoprotectants on glycogen phosphorylase activity and structure"

Kimberly A. Watson, Claire McCleverty, Silvano Geremia, Silvain Cottaz, Hughes Driguez, Louise N. Johnson, The EMBO Journal, 1999, 18, 4619. "Phosphorylase recognition and phosphorylysis of its oligosaccharide substrate: Answers to a long outstanding question"

Mark O'Reilly,Т Kimberly A. Watson, Louise N. Johnson,Т Biochemistry, 1999, 38, 5337-5345. "The crystal structure of theТ E.coliТ maltodextrin phosphorylase-acarbose complex"

Marc O'Reilly,Т Kimberly A. Watson, Reinhard Schinzel, Dieter Palm and Louise N. Johnson,Т Nature Structural Biology, 1997, 4, 405-412. "Oligosaccharide substrate binding inТ Escherichia colimaltodextrin phosphorylase"

Manuel Pastor, Gabriele Cruciani andТ Kimberly A. Watson,Т J. Med. Chem., 1997,Т 40, 4089-4102. "A Strategy for the Incorporation of Water Molecules Present in a Ligand-Binding Site into a 3D-QSAR Analysis"

Kimberly A. Watson, Reinhard Schinzel, Deiter Palm and Louise N. Johnson,Т The EMBO Journal, 1997,Т 16, 1-14. "The crystal structure ofТ Escherichia coliТ maltodextrin phosphorylase provides an explanation for the activity without control in this basic archetype of a phosphorylase"

91ЕМКН